MatrixCode: matrisome pathology
© Alexander Nyström
Research Focus 2021/22: MatrixCode: matrisome pathology
The “extracellular matrix” (ECM) encompasses all secreted, deposited, and soluble proteins in the interstitial milieu. In recent years, our perspective on ECM has changed on the functional and protein level, as we now understand the ECM less as a passive “scaffold”, and more as integral part of the diverse, complex, and dynamic signaling environment sustaining healthy tissue. By improved understanding of these complex aspects of the so-called “matrisome”, our opportunities to develop targeted therapies interacting with these processes in disease, scarring, and regeneration will be strengthened. The MatrixCode project aims to decipher how pathophysiological signaling depends on biochemical and biophysical modifications of the ECM. MatrixCode is compiled of four sub-projects focusing on different aspects of ECM signaling within wound healing and tumor biology. MatrixCode will strengthen ECM research in Freiburg by creating a critical mass of scientists, and strengthening ties to collaboration partners in Strasburg and worldwide. MatrixCode will lay the foundation for subsequent collaborative funding initiatives.
Members of the resarch focus team
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Albert-Ludwigs-Universität Freiburg Maria.asplund@imtek.uni-freiburg.de |
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PD Dr. rer. nat. Susana Minguet Institut für Biologie III Albert-Ludwigs-Universität Freiburg |
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Dr. rer. nat. Alexander Nyström Universitätsklinikum Freiburg Klinik für Dermatologie und Venerologie |
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Prof. Dr. rer. nat. Winfried Römer Zentrum für biologische Signalstudien Albert-Ludwigs-Universität Freiburg |
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PD Dr. rer. nat. Dr. med. Christoph Schell Institut für Klinische Pathologie Universitätsklinikum Freiburg |
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Prof. Dr. rer. nat. Dr. med. Oliver Schilling Institut für Klinische Pathologie Albert-Ludwigs-Universität Freiburg |
