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You are here: FRIAS Fellows Fellows 2021/22 Dr. Maria Asplund

Dr. Maria Asplund

Uni Freiburg © Foto: Klaus Polkowski
University of Freiburg
Bioelectronic Microtechnology

Internal Senior Fellow
October 2021 – July 2022

Room 01 026
Phone +49 (0)761 - 203 67375
Fax +49 (0)761 203 97451

CV

Maria Asplund is an expert in bioelectronics. Her research interests include flexible microtechnology, tissue-device interaction and electronic biomaterials. She completed her PhD at the Royal Institute of Technology (Stockholm, 2009) and is, since 2011, head of her research group Bioelectronic Microtechnology at the Department of Microsystems Engineering, University of Freiburg in Germany. Her work has resulted in new technologies which contributes to smaller, more energy efficient and durable bioelectronics in the future. In her ERC Starting Grant (2017) SPEEDER she is developing a new bioelectronic concept for tissue engineering of skin. Furthermore, she holds a Guest Professorship at the University of Luleå (2019) and is a scientific editor of PLoS ONE.

Selected Publications

  • Leal, J, Jedrusik, N, Shaner, S, Boehler, C, Asplund, M. SIROF stabilized PEDOT/PSS allows biocompatible and reversible direct current stimulation capable of driving electrotaxis in cells, Biomaterials 275 (2021) 120949.doi: 10.1016/j.biomaterials.2021.120949

  • Boehler, C, Kleber, C, Martini, N, Xie, Y, Dryg, I, Stieglitz, T, Hofmann, UG, Asplund, M. Actively controlled release of Dexamethasone from neural microelectrodes in a chronic in vivo study. Biomaterials, 2017, 129:176–187.

  • Kleber, C, Bruns, M, Lienkamp, K, Rühe, J, Asplund, M. An interpenetrating, microstructurable and covalently attached conducting polymer hydrogel for neural interfaces, Acta Biomater, 2017, 58: 365‐75.

  • Boehler, C, Vieira, DM, Egert, U, Asplund, M. NanoPt—A Nanostructured Electrode Coating for Neural Recording and Microstimulation, ACS Appl Mater Interfaces, 2020, 12, 13, 14855–14865.

  • Boehler, C, Carli, S, Fadiga, L, Stieglitz, T, Asplund, M. Tutorial: Guidelines for standardized performance tests for electrodes intended for neural interfaces and bioelectronics. Nature Protocols, 2020,doi:10.1038/s41596‐020‐0389‐2.

FRIAS Research Project

MatrixCode: matrisome pathology

The “extracellular matrix” (ECM) encompasses all secreted, deposited, and soluble proteins in the interstitial milieu. In recent years, our perspective on ECM has changed on the functional and protein level, as we now understand the ECM less as a passive “scaffold”, and more as integral part of the diverse, complex, and dynamic signaling environment sustaining healthy tissue. By improved understanding of these complex aspects of the so-called “matrisome”, our opportunities to develop targeted therapies interacting with these processes in disease, scarring, and regeneration will be strengthened. The MatrixCode project aims to decipher how pathophysiological signaling depends on biochemical and biophysical modifications of the ECM. MatrixCode is compiled of four sub-projects focusing on different aspects of ECM signaling within wound healing and tumor biology. MatrixCode will strengthen ECM research in Freiburg by creating a critical mass of scientists, and strengthening ties to collaboration partners in Strasburg and worldwide. MatrixCode will lay the foundation for subsequent collaborative funding initiatives.