Prof. Dr. Stefan Günther
Prof. Dr. Stefan Günther studied Biology and Computer Science in Germany until 2005. He completed his PhD thesis at the Free University of Berlin in the field of Computational Biology in 2008. During his PhD thesis he worked on theoretical models for the prediction of molecular interactions. For this purpose, he applied and developed computational methods for text- and data-mining, sequence analysis, and structural biology. After his PhD he accepted a postdoctoral research fellowship in the International Research Training Group (IRTG), Berlin. The group focused on the field of genomics and systems biology of biomolecular networks. In addition to the education of doctoral students, Prof.
Guenther developed a new approach for the structure-based modeling of protein-protein complexes. Furthermore, the structure-function relationship of small molecules was an important research field during his post-doctorate. In 2009 he was appointed Junior-Professor at the Institute for Pharmaceutical Sciences at the University of Freiburg, Germany. The new field of Pharmaceutical Bioinformatics is now part of the study of Pharmaceutical Sciences. Consequently, he directed his research to the identification of new drugs in the emerging research field of epigenetics. In November 2015 he was appointed full Professor.
Amongst others he is a member of the German Pharmaceutical Society (DphG) and the Central European Oncology Society for Anticancer Drug Research (CESAR).
4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). Hügle M, Lucas X, Weitzel G, Ostrovskyi D, Breit B, Gerhardt S, Einsle O, Günther S, Wohlwend D. J Med Chem. 2016 Feb 25;59(4):1518-30.
StreptomeDB 2.0-an extended resource of natural products produced by streptomycetes. Klementz D, Döring K, Lucas X, Telukunta KK, Erxleben A, Deubel D, Erber A, Santillana I, Thomas OS, Bechthold A, Günther S. Nucleic Acids Res. 2016;44:D509-D514.
The Purchasable Chemical Space: A Detailed Picture. Lucas X, Grüning BA, Bleher S, Günther S. J Chem Inf Model. 2015;55:915-924.
Using chiral molecules as an approach to address low-druggability recognition sites. Lucas X, Günther S. J Comput Chem. 2014;35:2114-2121.
4-Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading.
Lucas X, Wohlwend D, Hügle M, Schmidtkunz K, Gerhardt S, Schüle R, Jung M, Einsle O, Günther S. Angew Chem Int Ed Engl. 2013;52:14055-14059.
Epigenetics is one of the major topics of modern biomedical research and is already a major focus in the Freiburg research landscape with international visibility. We will establish a Research Focus on Chemical Epigenetics that deals with epigenetic mechanisms on a molecular level using our combined expertise in synthetic organic and medicinal chemistry, structural biochemistry and bioinformatics to address this topic in a highly synergistic manner. The main scientific focus of our project will be acetyl and methyl lysine binding proteins, so called histone code readers. Structural analyses provide the basis for identification and optimization of new chemical ligands for these proteins in a rational, bioguided fashion. This will lead to new chemical tools that will allow dissecting cellular pathways involving these proteins as well as the analysis of their suitability as targets in drug discovery. The structural aim of this project is the preparation of a proposal for a structured PhD programme in Chemical Epigenetics with a strong international education perspective.