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Prof. Joseph Klafter: "Proteins: a showcase of strange kinetics"

Wann 16.02.2009
von 11:15 bis 12:15
Wo FRIAS Seminarraum, Albertstr. 19
Kontakttelefon +49 (761) 203 97418
Teilnehmer Universitäts öffentlich
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Professor Joseph Klafter
External Senior Fellow of the Freiburg Institute for Advanced Studies


Proteins: a showcase of strange kinetics

There has been growing evidence, based on single molecule measurements and on molecular dynamics calculations, that proteins display strange kinetics. Namely, their dynamics is characterized by slow relaxation of correlations, by anomalous diffusion, and by broad distributions of unfolding times and of enzymatic reaction rates. Time-dependent observables show usually multi-exponential, stretched exponential or power law behavior. We will review a few examples and introduce a protein network model that may account for some of these observed properties. The model, which suggests fractal-like characteristics of proteins, also accounts for the necessary coexistence of protein stability and flexibility. An "equation of state" for proteins is proposed and verified for a large set of protein structures taken from the PDB.