Professor Michael J. Krische obtained a B.S. degree in Chemistry from the University of California at Berkeley, where he performed research under the tutelage of Professor Henry Rapoport. After one year of study abroad as a Fulbright Fellow, he initiated graduate research at Stanford University under the mentorship of Professor Barry Trost as a Veatch Graduate Fellow. Following receipt of his Ph.D. degree, he worked with Jean-Marie Lehn at the Université Louis Pasteur as an NIH Post-Doctoral Fellow. In Fall 1999, Professor Krische was appointed Assistant Professor at the University of Texas at Austin. He was promoted directly to Full Professor in Fall 2004 and in Fall 2007 he received the Robert A. Welch Chair in Science.
Selected Honours and Awards:
Novartis Chemistry Lectureship Award (2008), Presidential Green Chemistry Award (2007), Dowpharma Prize (2007), ACS Elias J. Corey Award (2007), Solvias Ligand Prize (2006), Society of Synthetic Chemistry Japan Lectureship (2005), Johnson & Johnson Focused Giving Award (2005), Dreyfus Teacher Scholar Award (2003), Alfred P. Sloan Research Fellowship (2003), Cottrell Scholar Award (2002), Frasch Foundation Award in Chemistry (2002), Lilly Grantee Award (2002), National Science Foundation-CAREER Award (2000), Maître de Conference, Collége de France (1999), NIH Post-Doctoral Fellow (1997), Veatch Graduate Fellow (1995), Sigma Xi Grantee (1991), Fulbright Fellow (1990).
Asymmetric hydrogenation accounts for over half the chiral compounds made by man, withstanding physical or enzymatic resolution. Whereas conventional hydrogenation involves C-H bond formation, our research establishes hydrogenation as a method for C-C bond formation. We have shown that hydrogenation and transfer hydrogenation may be used to couple diverse p-unsaturated reactants to carbonyl compounds, imines and even alcohols offering a byproduct-free alternative to stoichiometrically preformed organometallics in a range of classical C=X (X = O, NR) addition processes. These studies represent the first systematic efforts to exploit hydrogenation in C-C couplings beyond alkene hydroformylation and define a departure from the use of preformed organometallic reagents in carbonyl addition.
- “Diastereo- and Enantioselective Hydrogenative Aldol Coupling of Vinyl Ketones: Design of Effective Monodentate TADDOL-Like Phosphonite Ligands,” Bee, C.; Han, S. B.; Hassan, A.; Iida, H.; Krische, M. J. J. Am. Chem. Soc. 2008, 130, 2747.
- “Enantioselective Iridium Catalyzed Imine Vinylation: Optically Enriched Allylic Amines via Alkyne-Imine Reductive Coupling Mediated by Hydrogen,”Barchuk, A.; Ngai, M.-Y.; Krische, M. J. J. Am. Chem. Soc. 2007, 129, 12644.
- “Enantioselective Reductive Coupling of Acetylene to N-Arylsulfonyl Imines via Rhodium Catalyzed C-C Bond Forming Hydrogenation: (Z)-Dienyl Allylic Amines,” Skucas, E.; Kong, J.-R.; Krische, M. J. J. Am. Chem. Soc. 2007, 129, 7242.
- “Enantioselective Reductive Coupling of 1,3-Enynes to Heterocyclic Aromatic Aldehydes and Ketones via Rhodium Catalyzed Asymmetric Hydrogenation: Mechanistic Insight into the Role of Brønsted Acid Additives,” Komanduri, V.; Krische, M. J. J. Am. Chem. Soc. 2006, 128, 16448.