Molecular Medicine and Cell Research
Postdoc with PI Melanie Börries
Martin finished his diploma in Biochemistry in 2005 at the University of Bayreuth. In 2005 he started his PhD thesis under supervision of Prof. Dr. Markus Missler at the Center of Physiology and Pathophysiology at the University Göttingen. In 2006 he moved with the group to the Department of Anatomy at the University Münster, where he completed in 2010 his PhD thesis. The main subject of his thesis was to study the molecular interactions of the transsynaptic Neurexin-Neuroligin-Neurexophilin-Complex. In August 2011, he joined Melanie Börries within the group of Hauke Busch as a postdoctoral fellow in the School for Life Science-LifeNet at FRIAS located at the ZBSA.
Within the BMBF funded Nephage consortium, Martin Klose uses a systems biology approach to understand molecular processes of ageing in the kidney through the in vitro study of podocytes, the most vulnerable cell type. Based on high-throughput analysis of primary podocytes, comparison with other organisms like Drosophila flies and C. elegans worms and signaling pathway analysis, he investigates the dynamic response and compensation processes in young and old immortalized podocyte strains. This will provide a complementary and well standardized system to reveal the processes of kidney ageing.
- C. Reissner, M. Klose, R. Fairless, M. Missler (2008). Mutational analysis of the neurexin/neuroligin complex reveals essential and regulatory components. Proc Natl Acad Sci USA 105, 15124-15129.