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Irina Kratschmorova: "Dynamics of the skeletal muscle secretome during myoblast differentiation"

Wann 06.12.2010
von 11:15 bis 12:00
Wo FRIAS Seminarraum, Albertstr. 19, 79104 Freiburg
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Irina Kratschmorova
Center for Experimental BioInformatics, University of Southern Denmark, DK-Odense


Dynamics of the skeletal muscle secretome during myoblast differentiation

During recent years, increased efforts have focused on elucidating the secretory function of skeletal muscle. Through secreted molecules, skeletal muscle affects local muscle biology in an auto/paracrine manner as well as having systemic effects on other tissues. Here we used a quantitative proteomics platform to investigate the factors secreted during the differentiation of murine C2C12 skeletal muscle cells. We have identified and quantitatively analyzed 635 secreted proteins including 35 growth factors, 40 cytokines and 36 metallopeptidases. The extensive presence of these proteins that can act as potent signaling mediators to other cells and tissues strongly highlights the important role of the skeletal muscle as a prominent secretory organ.