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A pair of RNA scissors with many functions

Team of researchers led by FRIAS Felllow Wolfgang Hess publishes article in Nature Microbiology

Together with a research team from the University of Freiburg, Wolfgang Hess, member of the Freiburg-Strasbourg Joint Research Group “MapRNA: Mapping RNA-RNA pairings in vivo in bacteria and their importance in fast acclimation processes”, and Annegret Wilde, FRIAS Director for the Natural and Life Sciences, Medicine, Engineering, have published an article in Nature Microbiology. The team, led by Juliane Behler and FRIAS fellow Wolfgang Hess, have identified an enzyme, a special pair of RNA scissors, which is involved in CRISPR/Cas systems and the correct regulation of gene expression – in other words, in reading genes and translating their information into proteins.

Juliane Behler, Kundan Sharma, Viktoria Reimann, Annegret Wilde, Henning Urlaub, and Wolfgang R. Hess (2018): The host-encoded RNase E endonuclease as the crRNA maturation enzyme in a CRISPR–Cas subtype III-Bv system. Nature Microbiology. doi: 10. 1038/s41564-017-0103-5

More information is available in the press release