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You are here: FRIAS Events Staudinger Lectures Dec 14, 2015: Nobel Laureate …

22nd Hermann Staudinger Lecture with Nobel Laureate Paul Nurse

Paul Nurse_HSL

Paul Nurse received the 2001 Nobel Prize in Physiology or Medicine along with Leland Hartwell and Tim Hunt for their discoveries of protein molecules that control the division of cells in cell cycle. He is President of the Royal Society and, since 2011, Director of the Francis Crick Institute in London.

Picture © BBC

“Controlling the Cell Cycle”
When Dec 14, 2016
from 04:15 PM to 05:30 PM
Where Lecture Hall Pathology/Anatomy, Albertstr. 19
Contact Name
Contact Phone +49 (0)761 203-97407
Attendees öffentlich / open to the public
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Paul Nurse received the 2001 Nobel Prize in Physiology or Medicine along with Leland Hartwell and Tim Hunt for their discoveries of protein molecules that control the division of cells in cell cycle. He is President of the Royal Society and, since 2011, Director of the Francis Crick Institute in London.

The cell cycle consists of several defined steps that lead to cell division and cell reproduction. Several regulators control all phases of the cell cycle in order to prevent the division and reproduction of defective cells. Paul Nurse was able to identify one of these regulators called the cyclin-dependent kinase. In his lecture, Paul Nurse will specify the role of the activity of cyclin-dependent kinases in different phases of the cell cycle. Since a defective regulation of the cell cycle can lead to an uncontrolled cell growth, researchers assume a causal relation between the cell cycle and cancer formation.



Abstract: “Controlling the Cell Cycle”

Both S-phase and mitosis are common to all cell cycles and both are necessary for the two newly divided cells to receive a full complement of genes.  In fission yeast the onset of S-phase and mitosis can be controlled by a single cyclin dependent kinase with different levels of CDK activity bringing about progression through the cell cycle in an orderly fashion.  Using phosphoproteomics we show that a low CDK activity is sufficient to bring about S-phase whilst a high activity blocks a further S-phase and is needed for onset of mitosis.  A G2 cell can be programmed to undergo either S-phase or mitosis simply by modifying CDK activity indicating there is no inherent direction in the cell cycle.