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21st Hermann Staudinger Lecture with Nobel Laureate Randy Schekman

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21st Hermann Staudinger Lecture with Nobel Laureate Randy Schekman (University of California, Berkeley)

March 9, 2016

4:15 pm, Anatomy Lecture Hall, Albertstr. 19, Freiburg

Unconventional secretion of proteins and RNA from cultured human cells
When Mar 09, 2016
from 05:15 PM to 07:00 PM
Where Anatomy Lecture Hall, Alberstr. 19, 79104 Freiburg
Contact Name
Contact Phone +49(0)761 203-97407
Attendees öffentlich / open to the public
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Lecture on "Unconventional secretion of proteins and RNA from cultured human cells"

Report (Julia Donauer)

Randy Schekman received the 2013 Nobel Prize for Physiology or Medicine together with James Rothman and Thomas C. Südhof for their pioneering work on cell membrane vesicle trafficking. After an inspiring and enjoyable day at FRIAS, where Randy Schekman discussed scientific questions and the prominence of the open access journal eLife with selected researchers from Freiburg, his lecture followed as the highlight of the day.  With the title “Unconventional secretion of proteins and RNA from cultured human cells”, he presented his impressive results on the secretion pathway of large particles such as lipoproteins, collagen and extracellular vesicles. With a clear statement by Schekman in favor of open access journals, the scientific exchange came to an end with a nice get together in front of the anatomy lecture hall.

On March 9, 2016, at 4:15 pm, the 21st Hermann Staudinger Lecture with Nobel Laureate Randy Schekman (Howard Hughes Medical Institute, University of California, Berkely) will take place at the Anatomy Lecture Hall, Albertstr. 19.

In his research, Randy Schekman deals with intra- and extracellular transport processes of proteins. He is interested in the question of how cellular proteins orient themselves inside and outside of cells. Ornganelle- and membrane proteins are usually transported towards the endoplasmic reticulum, a cellular membrane network. From there, so called vesicles, i.e. small bubbles enclosed by a membrane, pinch off in order to transport the proteins from the endoplasmic reticulum to the Golgi apparatus, a cellular organ that serves as a reactive center, further processing the proteins. During the transport process, those vesicles send out messenger substances that are sent through the cells towards the cell surface and to other cells in the body.

In his research, Randy Schekman deals with exactly those vesicles and the machinery of their transport system. Already in the 1970s he was interested in how proteins move inside and outside of cells, starting with research on cellular transport systems in yeast. In 2013, he received the Nobel Prize for Physiology/Medicine, together with James Rothman and Thomas Südhof, for their research on cell transport systems.

Schekmans research produced important findings on the functionality of cells and enabled a better understanding for diseases such as diabetes or immune disorders.


Abstract of the lecture

Large particles, such as lipoproteins, collagen and extracellular vesicles are secreted from animal cells in vivo and in cell culture.  These particles represent a challenge for the normal secretory machinery. We have found that the rigid rod of procollagen can be accommodated in a giant transport vesicle dependent on the usual machinery involved in traffic from the endoplasmic reticulum.

Extracellular vesicles are secreted by budding into an endosome or from the cell surface.  Extracellular vesicles package a select set of micro RNAs that are sorted by an RNA binding protein and are dependent on a short nucleotide sequence that constitutes an RNA sorting signal.