19th Hermann Staudinger Lecture with Nobel Laureate Brian K. Kobilka
The Hermann Staudinger Lectures are a series of talks initiated by the former FRIAS School of Soft Matter Research in 2008. FRIAS invites international Nobel Laureates to give a lecture in Freiburg two to three times a year. The lecture series is named after Nobel Laureate Hermann Staudinger who taught at the University of Freiburg from 1926–1951 and was awarded the Nobel Prize in Chemistry in 1953.
This lecture is open to the public.
Date: June 9, 2015
Venue: Pathologie/Anatomie, Albertstr. 19, 79104 Freiburg
Structural insights into the dynamic process of G protein coupled receptor signaling
G protein coupled receptors (GPCRs) conduct the majority of transmembrane responses to hormones and neurotransmitters, and mediate the senses of sight, smell and taste. The b2 adrenergic receptor (b2AR), the M2 muscarinic receptor and the mu-opioid receptor are prototypical Family A GPCRs. We have obtained three-dimensional structures of these receptors in inactive and active conformations, as well as a structure of the b2AR in complex with the G protein Gs. Comparison of these structures provides insights into common mechanisms for propagation of conformational changes from the agonist binding pocket to the G protein coupling interface. We have also used fluorescence, EPR and NMR spectroscopy to study the dynamic properties of the β2AR. I will discuss what we these studies have taught us about allosteric regulation of GPCR structure by G proteins and ligands.