Sie sind hier: FRIAS School of Soft Matter … Veranstaltungen Rolf Backofen: "RNA Dark Matter"

Rolf Backofen: "RNA Dark Matter"

Wann 10.05.2010
von 11:15 bis 12:00
Wo FRIAS Seminarraum, Albertstr. 19, 79104 Freiburg
Kontakttelefon +49 (0)761 203 97418
Teilnehmer Open to University employees
Termin übernehmen vCal

Prof. Rolf Backofen
Department of Computer Science, University of Freiburg


RNA Dark Matter

In the past years, the common view of RNA has evolved from a more or less boring in-termediate in protein translation to a very important player in cell regulation. The changed role was primarily the result of the detection of thousands of non-coding RNAs with many different regulatory functions in post-translational regulation. New experimen-tal evidence indicate that while only ~1% of the human genome is translated into pro-teins, about 80%-90% of the genome is transcribed into non-coding RNA. This vast layer of regulation was remained hidden from the view until just recently.

We will discuss various topics related to the analysis of non-coding RNAs especially on the boundary of biology and soft matter. Main biological problems is the finding of non-coding RNAs as well as the decection of putative RNA targets. Both problems require the prediction of (secondary) structures, which is usually done using a thermodynamic approach. However, it is well known that the kinetic aspects and the energy landscape of secondary structure plays an important role as well.