Noam Agmon: "Proton Mobility in Water and Proteins"
| Wann |
10.05.2012 von 13:15 bis 14:00 |
|---|---|
| Wo | FRIAS Seminar Room, Albertstr. 19, 79104 Freiburg |
| Name | Silke Trötschel |
| Kontakttelefon | +49-(0)761-203-97445 |
| Teilnehmer |
Open to University employees |
| Termin übernehmen |
vCal
iCal
|
Noam Agmon
Department of Physical Chemistry, Hebrew University, Jerusalem, Israel
Proton Mobility in Water and Proteins
Proton mobility is important for reactions in solution and biological systems. Recent studies reveal a range of mechanisms, more stochastic in bulk liquid water, concerted multi-proton hopping along short water-wires connecting acid and base in solution, and a "proton collecting antenna" in the green fluorescent protein (GFP).
In room temperature bulk water, MS-EVB simulations revealed a dynamically distorted hydronium (H3O+) undergoing the "special pair dance". Eventually a protonated dimer (H5O2+ cation) is formed, allowing proton hopping between these two water molecules. The IR band of this "proton-transfer mode" has been identified using a "clusters-in-liquid" approach.
A high resolution X-ray structure of GFP revealed an internal wire connecting its chromophore to a putative "proton collecting antenna" on a negative surface patch. It could possibly be recruiting a proton from solution to replenish that which escaped following photo-excitation.
