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Ulrich auf dem Keller: "SkiNterminomics: dissecting proteolytic pathways in the skin"

Wann 12.05.2011
von 13:15 bis 14:00
Wo FRIAS Lecture Hall, Albertstr. 19, 79104 Freiburg
Kontakttelefon +49 761 203 97154
Teilnehmer Open to University employees
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Ulrich auf dem Keller
Institute of Cell Biology, ETH Zürich



Dissecting proteolytic pathways in the skin

Proteases play pivotal roles in normal skin homeostasis and its responses to inflammation and injury. Importantly, aberrant protease activity has been identified as a contributor to inflammatory skin diseases and the pathogenesis of chronic wounds. To further unravel the mechanisms of protease action in skin inflammation and repair, we have applied iTRAQ-TAILS, a novel multiplex quantitative proteomics platform for the analysis of N-terminomes, to dissect proteolytic pathways in normal and inflamed mouse skin as well as in a porcine wound healing model. This analysis revealed known proteolytic pathways, such as blood coagulation and complement activation, but also unexpected substrate cleavages and interactions of proteolytic systems.