Ulrich auf dem Keller: "SkiNterminomics: dissecting proteolytic pathways in the skin"
| Wann |
12.05.2011 von 13:15 bis 14:00 |
|---|---|
| Wo | FRIAS Lecture Hall, Albertstr. 19, 79104 Freiburg |
| Name | Hauke Busch |
| Kontakttelefon | +49 761 203 97154 |
| Teilnehmer |
Open to University employees |
| Termin übernehmen |
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Ulrich auf dem Keller
Institute of Cell Biology, ETH Zürich
SkiNterminomics:
Dissecting proteolytic pathways in the skin
Proteases play pivotal roles in normal skin homeostasis and its responses to inflammation and injury. Importantly, aberrant protease activity has been identified as a contributor to inflammatory skin diseases and the pathogenesis of chronic wounds. To further unravel the mechanisms of protease action in skin inflammation and repair, we have applied iTRAQ-TAILS, a novel multiplex quantitative proteomics platform for the analysis of N-terminomes, to dissect proteolytic pathways in normal and inflamed mouse skin as well as in a porcine wound healing model. This analysis revealed known proteolytic pathways, such as blood coagulation and complement activation, but also unexpected substrate cleavages and interactions of proteolytic systems.
