Niels Grabe: "EPISYS: Measuring and Modelling Epidermal Homeostasis"
| Wann |
06.07.2009 von 11:15 bis 12:15 |
|---|---|
| Wo | FRIAS Seminarraum, Albertstr. 19 |
| Name | Britta Küst |
| Kontakttelefon | +49 (0)761 203 97418 |
| Teilnehmer |
Universitäts öffentlich |
| Termin übernehmen |
vCal
iCal
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Prof. Niels Grabe
Institute of Medical Biometry and Informatics, University Hospital Heidelberg
EPISYS: Measuring and Modelling Epidermal Homeostasis
Epidermal tissue homeostasis is a complex but ideal field of study for systems biology. The works in the group are directed towards a technical platform for researching the homeostasis of epithelial tissue, which would be an important contribution to medical applications of systems biology. Experimentally, EPISYS develops approaches for quantifying epidermal homeostasis by spatial profiling of biomarker expression patterns using indirect immunofluorescence of cryo and paraffin tissue sections. Microscopy is performed using automated whole-slide scanner (virtual microscopy). Subsequent image processing reconstructs spatiotemporal networks of epidermal differentiation markers. On the modelling side, a platform for the multi-cellular simulation of the epidermis using finite state machines is developed. Recent experimental and theoretical results are shown and the impact of whole-slide scanning for developing systems biology into systems pathology emphasized.
