Sie sind hier: FRIAS School of Life Sciences … Veranstaltungen T. Keith Blackwell: "Systemic …

T. Keith Blackwell: "Systemic detoxification, insulin-like signaling, and aging in C. elegans"

Wann 27.07.2009
von 17:15 bis 18:15
Wo Hörsaal Zoologie, Hauptstrasse 1
Kontakttelefon +49 (0)761 203 97418
Teilnehmer Universitäts öffentlich
Termin übernehmen vCal

Professor T. Keith Blackwell
Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, Joslin Diabetes Center, Boston, USA


Systemic detoxification, insulin-like signaling, and aging in C. elegans

One of the most exciting observations of recent years is that insulin/IGF-1-like signaling (IIS) and other genetically defined mechanisms have profound effects on longevity in model organisms. We are using the C. elegans model to study a transcription regulator (SKN-1) that controls several mechanisms that detoxify free radicals and other reactive molecules, or repair cellular structures. In my lecture, I will describe studies of SKN-1 that shed light on IIS and other mechanisms that influence longevity, and that reveal remarkable complexity in organismal defenses against stress.