17th Hermann Staudinger Lecture with Nobel Prize Laureate Erwin Neher
"Modulation of Short-Term Plasticity at the Calyx of Held Synapse"
Nobel Laureate Erwin Neher
Nobel Prize in Physiology or Medicine 1991
| When |
Sep 05, 2014
from 08:00 PM to 09:00 PM |
|---|---|
| Where | Lecture Hall Otto Krayer-Haus, Albertstraße 25, 79104 Freiburg |
| Contact Name | Dr. Britta Küst |
| Contact Phone | +49 (0)761-203 97418 |
| Attendees |
Öffentlich / open to the public |
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Modulation of Short-Term Plasticity at the Calyx of Held Synapse
Short-term plasticity is highly modulated by second messengers, such as Ca++ and diacylglycerol (DAG). At the Calyx of Held, there is pronounced heterogeneity between individual synapses, some showing moderate to strong depression during stimulus trains of 100 Hz or 200 Hz, others displaying a sequence of facilitation and depression. After application of phorbol ester, mimicking the effect of DAG, EPSCs are enlarged and strong depression is observed only. Lee and colleagues showed (2013, PNAS) that application of DAG accelerates a process, which they termed ‘superpriming’, a slow transition of release-ready vesicles from a ‘normally’ primed state to a faster, ‘superprimed’ one. Some evidence will be shown, which suggests that the heterogeneity between synapses is due to different degrees of ‘superpriming’ at rest.
