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Matthias Huber

Molecular Biology
Postdoc with Junior Fellow Stefan Schiller


    Matthias Huber studied Biology at the Albert-Ludwigs University Freiburg, Germany. He complete his diploma thesis in molecular biology in 1993 in the department of Prof. Dr. Albrecht Sippel. After receiving his PhD on reorganisation of chromatin structure and gene regulation in 1996 in the group of Dr. Constanze Bonifer he stayed there as a postdoctoral fellow. In 1998 he started in the F&E department of BioChip Technology GmbH as a group leader in method development. He moved in 2000 to the company Biosynthetics GbR as head of laboratory and project director with the topic synthetic genes and synthetic biology. In 2001 he cofounded the Biosynthetics GmbH. He resigned in 2002 to work the following years in the IT security company Justec GmbH. From 2006 to 2008 he joined the laboratory of Prof. Dr. Roland Schüle in the Centre for Clinical Research at the University Hospital Freiburg. In 2008, he joined the Freiburg Institute for Advanced Studies (FRIAS) School for Soft Matter Research at the Albert Ludwigs University in Freiburg as a postdoc in the group of Dr. Stefan Schiller. The group is focus on combining macromolecular chemistry with synthetic biology. Genetic engineering, protein design and optimization and metabolic engineering of microbial systems give rise to new biohybrid materials and new functional biomolecular complexes and pathways in future.


    FRIAS Project

    Biohybrid Nanoscience and Materials

    Biohybrid materials - combining macromolecular chemistry and synthetic biology, genetically encoded unnatural amino acids; structural and functional molecular LEGO in nanobiotechnology. Multifunctional building blocks for dynamic self-guiding nano circuit assemblies in molecular electronics. Enzyme and pathway engineering for green polymer chemistry and development of renewable monomers and biofuel.


    Selected Publications

    1. Huber, M.C. and Bonifer, C. (1998). The activation of the chicken lysozyme locus is a cooperative process. Gene Ther. Mol. Biol. 3:1-13.
    2. Bonifer C, Jägle U, Huber MC. (1997) The chicken lysozyme locus as a paradigm for the complex developmental regulation of eukaryotic gene loci. J Biol Chem. 272(42):26075-8. Review
    3. Huber MC, Jägle U, Krüger G, Bonifer C. (1997) The developmental activation of the chicken lysozyme locus in transgenic mice requires the interaction of a subset of enhancer elements with the promoter. Nucleic Acids Res. 25 (15):2992-3000.
    4. Bonifer C, Huber MC, Jägle U, Faust N, Sippel AE. (1996) Prerequisites for tissue specific and position independent expression of a gene locus in transgenic mice. J Mol Med. 74(11):663-71. Review.
    5. Huber MC, Krüger G, Bonifer C. (1996) Genomic position effects lead to an inefficient reorganization of nucleosomes in the 5'-regulatory region of the chicken lysozyme locus in transgenic mice. Nucleic Acids Res. 24(8):1443-52.
    6. Huber MC, Graf T, Sippel AE, Bonifer C. (1995) Dynamic changes in the chromatin of the chicken lysozyme gene domain during differentiation of multipotent progenitors to macrophages. DNA Cell Biol. 14(5):397-402.