Prof. Michael J. Krische: "Formation of C-C Bonds via Catalytic Hydrogenation and Transfer Hydrogenation"
von 17:15 bis 18:15
|Wo||Lecture hall, Chemistry building|
Professor Michael J. Krische,Robert A.
Welch Chair in Science, Department of Chemistry, University of Texas at Austin
Asymmetric hydrogenation accounts for over half the chiral compounds made by man, withstanding physical or enzymatic resolution. Whereas conventional hydrogenation involves C-H bond formation, our research establishes hydrogenation as a method for C-C bond formation. We have shown that hydrogenation and transfer hydrogenation may be used to couple diverse Π-unsaturated reactants to carbonyl compounds, imines and even alcohols, thus offering a byproduct-free alternative to stoichiometrically preformed organometallics in a range of classical C=X (X = O, NR) addition processes. These studies represent the first systematic efforts to exploit hydrogenation in C-C couplings beyond hydroformylation and define a departure from the use of preformed organometallic reagents in carbonyl addition.