Zentrum für Biosystemanalyse
Melanie Börries finished her medical school in 2001 at the University of Lübeck, Germany. From 2001-2005 she has carried out an MD-PhD program in Cell Biology at the M.E. Müller Institute for Structural Biology in the Biozentrum at the University of Basel (Switzerland) under supervision of PD Dr. Cora-Ann Schoenenberger and Prof. Ueli Aebi. For her PhD thesis, she dissected novel regulatory mechanisms of the Ca2+-binding protein S100A1 on cardiac function by a combination of molecular cell biology, biochemistry, biophysics and structural biology. During her MD-PhD program she received her medical doctor (MD) in 2004 and did two clinical internships at the Swiss Cardiovascular Center Bern (Switzerland) to complete her medical training. After her MD-PhD program she worked as a postdoctoral fellow from 2005-2009 in the Institute for Pharmacology and Toxicology at the University of Freiburg, Germany. Since March 2009 she joined the Freiburg Institute for Advanced Studies (FRIAS) at the Albert-Ludwigs University Freiburg as a postdoctoral fellow in the research group of Hauke Busch.
The group of Hauke Busch focuses on the development and verification of mathematical models for cellular behavior from an initial stimulus to the final phenotype. In a systems biology approach we combine experimental research on cell-cell communication with the development of appropriate multi-scale dynamic models to investigate the necessary and sufficient control points that lead to cell proliferation, differentiation, migration or death. In this context Melanie Börries will coordinate the experimental set-up as a project leader.
- A. Heinemann, Y. He, M. Börries, H. Busch, L. Bruckner-Tuderman, C. Has: Induction of Phenotype Modifying Cytokines by FERMT1 Mutations Hum Mutat, 2011; 32 (4): 397-406
- A. Sprenger, V. Küttner, M.L. Biniossek, C. Gretzmeier, M. Boerries, C. Mack, C. Has, L. Bruckner-Tuderman, J. Dengjel: Comparative quantitation of proteome alterations induced by aging or immortalization in primary human fibroblasts and keratinocytes for clinical applications Molecular Biosystems, 2010; 6 (9): 1579-1582
- M. Boerries, R. Eils, H. Busch: Systems Biology In: Encyclopedia of Molecular Cell Biology and Molecular Medicine Wiley, 2010.
- M. Boerries*, P. Most*, JR. Gledhill, JE. Walker, HA. Katus, W.J. Koch, U. Aebi and CA.Schoenenberger. Ca2+-dependent interaction of S100A1 with the F1-ATPase leads to an increased ATP content in cardiomyoctes. Mol Cell Biol. 20 Jun;27(12):4365-73.
- Schoenenberger, CA., Buchmeier, S., Boerries, M., Sütterlin, R., Aebi, U. and Jockusch, B.M. Conformation-speciﬁc antibodies reveal distinct actin structures in the nucleus and the cytoplasm. J Struct Biol. 2005 Dec;152(3):157-68.
- Most P*, Boerries M*, Eicher C, Schweda C, Volkers M, Wedel T, Sollner S, Katus HA, Remppis A, Aebi U, Koch WJ, Schoenenberger CA. Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes. J Cell Sci. 2005 Jan 15;118(Pt 2):421-31.
- Most P, Pleger ST, Volkers M, Heidt B, Boerries M, Weichenhan D, Loffler E, Janssen PM, Eckhart AD, Martini J, Williams ML, Katus HA, Remppis A, Koch WJ. Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. J Clin Invest. 2004 Dec;114(11):1550-63.
- Most P*, Boerries M*, Eicher C, Schweda C, Ehlermann P, Pleger ST, Loeffler E, Koch WJ, Katus HA, Schoenenberger CA, Remppis A. Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2). J Biol Chem. 2003 Nov 28;278(48):48404-12.
- P. Most, J. Bernotat, P. Ehlermann, ST. Pleger, M. Börries, M. Reppel, F. Niroomand, B. Pieske, PM: Janssen, T. Eschenhagen, P. Karczewski, GL. Smith, WJ. Koch, HA. Katus, A. Remppis. S100A1: a regulator of myocardial contractility. Proc. Natl. Acad. Sci. USA (24): 13889-94. 2001.
*Authors contributed equally to this work.