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Tomohiro Kurosaki: "Unique Properties of Memory B Lymphocytes"

Wann 21.06.2010
von 11:15 bis 12:00
Wo FRIAS Seminarraum, Albertstr. 19, 79104 Freiburg
Kontakttelefon +49 (0)761 203 97418
Teilnehmer Open to University employees
Termin übernehmen vCal

Tomohiro Kurosaki
Lab of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Osaka and RCAI, RIKEN, Yokohama


Unique Properties of Memory B Lymphocytes

Understanding the mechanism by which memory B cells are generated and maintained, as well as defining the basis of their heightened responsiveness, is of fundamental inter-est to reveal the basis of immunological memory.
In terms of location of memory B cells, we have recently shown that NP-CGG-induced IgG1 type memory B cells resided adjacent to waned germinal centers (GCs) in the spleen. Since we also observed that CD4+ T cells existed in close proximity to IgG1 memory B cells, we would propose that this close proximity of memory IgG1 B cells to memory T cells can explain, at least partly, the more rapid kinetics of humoral memory responses.
In terms of longevity of memory B cells, we found that IgG1 type memory B cell homeo-stasis was severely hampered by inducible deletion of PLCy2. Based on these observa-tions, together with in vitro analysis, we would like to propose that a BCR signal, pre-sumably similar to that needed for the survival of naïve B cells, is required for mainte-nance of IgG1 type memory B cells, and that this survival signal is mediated by PLCy2.