Niko Beerenwinkel: "Evolution towards disease"
von 11:15 bis 12:00
|Wo||FRIAS Seminarraum, Albertstr. 19, 79104 Freiburg|
|Kontakttelefon||+49 761 203 97346|
Open to University employees
Computational Biology Group, ETH Basel
Evolution towards disease
Many human diseases are the result of evolutionary processes on time scales much shorter than the human lifetime. Prominent examples of pathogenic, measurably evolving populations are cancer cells in a tumor and infectious parasites, such as bacteria and viruses. Treatment of these constantly changing ensembles of individuals is complicated by evolutionary escape from the selective pressure of drugs and immune responses. I will present several statistical models for the evolutionary dynamics of escape and discuss applications to the genetic progression of cancer and to the development of drug resistance in HIV.