Ekaterina Shelest: "Search and prediction of transcription factor binding sites: challenges and solutions"
von 11:15 bis 12:00
|Wo||FRIAS Seminar Room, Albertstr. 19, 79104 Freiburg|
|Kontakttelefon||+49 (0)761-203 97207|
Open to University employees
Systems Biology/Bioinformatics research group, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute
Search and prediction of transcription factor binding sites: challenges and solutions
Prediction of transcription factor binding sites (TFBSs) is an important step in promoter modeling and network inference. However, quality of the predictions is spoiled by numerous false positives, which persist as the main problem for all presently available TFBS search methods. We suggested a novel method (SiTaR), which allows significant reduction the number of false positives. The quality of predictions can be further improved by consideration of TFBS combinations (binding sites of cooperating TFs), which can be accomplished with the tool DistanceScan. In my talk I will give a short overview and comparison of the existing methods for TFBS search.