Dr. Gunnar Cedersund - FRIAS LIFENET Seminar
|Wo||FRIAS Seminarraum, Albertstr. 19|
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Dr. Gunnar Cedersund
Progress and challenges in systems biology studies of type II diabetes
This project gives a basic introduction to systems biology, but also takes up two specific aspects: handling of complexity and multi-level modelling of glucose homoestasis.
The first aspect, handling of complexity and over-parametrisation, is a general problem shared by almost all systems biology studies. A key issue with this problem is that many model predictions are the result of arbitrary choices on large parameter manifolds, even though the simulation-data agreement is good. However, as I will stress in this talk, some model properties are not arbitrary, and I have developed techniques to identify such uniquely identifiable predictions in over-parametrised models, which I denote core predictions.
The second aspect deals with concrete projects related to type II diabetes.
I will review some recent developments in the characterisation of the insulin signalling network as well as attempts to integrate such insights and models on the cellular and organ levels, into models and insights for the whole-body level.
As you will see, some of these hierarchical models are now also starting to make their way into the pharmaceutical developments.