Prof. Wolfgang Driever "Studying complex systems in a simple model: from stem cells to dopaminergic neural system in zebrafish"

"Studying complex systems in a simple model: from stem cells to dopaminergic neural system in zebrafish"

Complex gene regulatory networks control differentiation of embryonic stem cells into defined neurons. A comprehensive understanding of the consecutive temporal states of these networks would be instrumental for the design of neuroregenerative therapies. However, in mammalian systems the complexity of spatially and temporally distinct states, and especially the lack of synchronicity of cell states has hindered a quantitative network understanding. Here, I will present our work using the zebrafish embryo as a simple model system, in which three major features simplify systems analysis:

1. synchronicity in development, enabling experimental dissection of consecutive temporal network states
2. ease of dissecting spatially distinct states, and
3. ease of interference with systems components. Temporal states and network features of the stem cell, neural precursor and differentiation networks will be discussed.