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MatrixCode: matrisome pathology

FRIAS is a place of lively interaction, research and international networks. These pages provide an overview of the topic areas that are being researched at FRIAS.

The interdisciplinary research focus "MatrixCode: matrisome pathology" investigates intercellular substance

MatrixCode: matrisome pathology

matrixCode Titelbild-4

© Alexander Nyström

Research Focus 2021/22: MatrixCode: matrisome pathology

 

The “extracellular matrix” (ECM) encompasses all secreted, deposited, and soluble proteins in the interstitial milieu. In recent years, our perspective on ECM has changed on the functional and protein level, as we now understand the ECM less as a passive “scaffold”, and more as integral part of the diverse, complex, and dynamic signaling environment sustaining healthy tissue. By improved understanding of these complex aspects of the so-called “matrisome”, our opportunities to develop targeted therapies interacting with these processes in disease, scarring, and regeneration will be strengthened. The MatrixCode project aims to decipher how pathophysiological signaling depends on biochemical and biophysical modifications of the ECM. MatrixCode is compiled of four sub-projects focusing on different aspects of ECM signaling within wound healing and tumor biology. MatrixCode will strengthen ECM research in Freiburg by creating a critical mass of scientists, and strengthening ties to collaboration partners in Strasburg and worldwide. MatrixCode will lay the foundation for subsequent collaborative funding initiatives. 


Members of the resarch focus team

 

asplund

Dr rer. nat. Maria Asplund

Microsystems engineering

Albert-Ludwigs-Universität Freiburg

minguet hochkant1

PD Dr. rer. nat. Susana Minguet

Institut für Biologie III

Albert-Ludwigs-Universität Freiburg

nyström

Dr. rer. nat. Alexander Nyström

Universitätsklinikum Freiburg

Klinik für Dermatologie und Venerologie

römer

Prof. Dr. rer. nat. Winfried Römer

Zentrum für biologische Signalstudien

Albert-Ludwigs-Universität Freiburg

schell hochkant1

PD Dr. rer. nat. Dr. med. Christoph Schell

Institut für Klinische Pathologie

Universitätsklinikum Freiburg

schilling

Prof. Dr. rer. nat. Dr. med. Oliver Schilling

Institut für Klinische Pathologie

Albert-Ludwigs-Universität Freiburg

oliver.schilling@mol-med.uni-freiburg.de