Sie sind hier: FRIAS Veranstaltungen Staudinger Lectures 29. Hermann Staudinger Lecture …

29. Hermann Staudinger Lecture mit Nobelpreisträger Bruce Beutler


Bruce Beutler

Regental Professor and Director of the Center for Genetics of Host Defense at the University of Texas Southwestern Medical Center

Nobel Laureate Physiology or Medicine 2011


Discovering TNF, TLRs, and other key components of the immune system
Wann 05.10.2022
von 16:15 bis 18:00
Wo FRIAS, Albertstr. 17, Anatomy Lecture Hall
Kontakttelefon +49 (0)761 203-97362
Teilnehmer öffentlich / open to public
Termin übernehmen vCal

Discovering TNF, TLRs, and other key components of the immune system

Quite early in my career, I isolated mouse TNF, a protein secreted by macrophages in response to lipopolysaccharide (LPS).  I determined that TNF mediated many LPS effects, including systemic inflammation, shock, and death.  My attention was thus drawn to the LPS receptor, which was responsible for alerting mammals to the presence of Gram(-) infection.  My colleagues and I identified it as Toll-like receptor 4 by positional cloning, then a five-year undertaking.  In so doing, we revealed an entire family of innate immune receptors that recognize molecular signatures of infection.  This experience led me to create many other immunological phenotypes through random germline mutagenesis, and we tracked them down one by one.  In recent years, my laboratory has developed automated meiotic mapping (AMM), which makes positional cloning an instantaneous procedure.  Using AMM, we have positionally ascribed approximately 30,000 phenotypes to individual mutations:  an accomplishment that only recently would have required thousands of years.  This has allowed us to identify the majority of genes needed for robust immunity, and also has opened the door to a systematic search for disease modifier mutations.