Prof. Dr. Bernhard Breit
Bernhard Breit studied chemistry at the University of Kaiserslautern, Germany where he obtained his doctorate in 1993 with Professor Regitz. After postdoctoral training with Professor Trost at Stanford University, he worked in Marburg, Germany, with Professor R. W. Hoffmann to obtain his habilitation in 1998. In 1999 he was appointed as an Associate Professor at the University of Heidelberg, Germany. Since 2001 he has been a Full Professor of Organic Chemistry at the Albert-Ludwigs-Universität Freiburg i. Brsg. His research interests focus on the exploration and development of catalytic methods for organic synthesis. He is author of more than 190 publications. He has been a visiting professor at Harvard and Stanford University and at the University of Strasbourg.
- Asymmetric synthesis of N-allylic indoles via regio- and enantioselective allylation of aryl hydrazines, Xu, K.; Gilles, T.; Breit, B. Nature Commun. 2015, DOI:10.1038/ncomms8616.
- Regio- and Enantioselective Synthesis of N-Substituted Pyrazoles by Rhodium-Catalyzed Asymmetric Addition to Allenes, Haydl, A. M.; Xu, K.; Breit, B. Angew. Chem. Int. Ed. 2015, 54, 7149–7153.
- Rhodium-Catalyzed Hydroformylation of 1,1-Disubstituted Allenes Employing the Self-Assembling 6-DPPon System, Köpfer, A.; Breit, B. Angew. Chem. Int. Ed. 2015, 54, 6913–6917.
- Enantioselective Redox-Neutral Rh-Catalyzed Coupling of Terminal Alkynes with Carboxylic Acids Towards Branched Allylic Esters, Koschker, P.; Kähny, M.; Breit, B. J. Am. Chem. Soc. 2015, 137, 3131–3137.
- Rhodium-Catalyzed Chemo-, Regio-, and Enantioselective Addition of 2-Pyridones to Terminal Allenes, Li, C.; Kähny, M.; Breit, B. Angew. Chem. Int. Ed. 2014, 53, 13780–13784.
Epigenetics is one of the major topics of modern biomedical research and is already a major focus in the Freiburg research landscape with international visibility. We will establish a Research Focus on Chemical Epigenetics that deals with epigenetic mechanisms on a molecular level using our combined expertise in synthetic organic and medicinal chemistry, structural biochemistry and bioinformatics to address this topic in a highly synergistic manner. The main scientific focus of our project will be acetyl and methyl lysine binding proteins, so called histone code readers. Structural analyses provide the basis for identification and optimization of new chemical ligands for these proteins in a rational, bioguided fashion. This will lead to new chemical tools that will allow dissecting cellular pathways involving these proteins as well as the analysis of their suitability as targets in drug discovery. The structural aim of this project is the preparation of a proposal for a structured PhD programme in Chemical Epigenetics with a strong international education perspective.