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You are here: FRIAS Events Staudinger Lectures To come: Oct 7, 2015 Nobel …

20th Hermann Staudinger Lecture with Nobel Laureate Andrew Z. Fire, October 7, 2015

Andrew Fire_HSL

"Cellular Response to Genetic Change"

Andrew Fire and Craig Mello were honoured with the Nobel Prize for Physiology or Medicine in 2006 for their discoveries related to gene silencing — a process that allows cells to selectively turn off specific genes.

"Cellular Response to Genetic Change"
When Oct 07, 2015
from 06:15 PM to 08:00 PM
Where Lecture Hall Pathology/Anatomy, Albertstr. 19
Contact Name
Contact Phone +49 (0)761 203-97407
Attendees öffentlich / open to the public
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In his research, Andrew Fire primarily makes use of the nematode C. elegans in experimental studies. C. elegans is small, easily cultured, and can readily be made to accept foreign DNA or RNA. The results of such experiments have outlined a number of concerted responses that recognize (and in most cases work to silence) the foreign nucleic acid. One such mechanism ("RNAi") responds to double stranded character in RNA: either as introduced experimentally into the organism or as produced from foreign DNA that has not undergone selection to avoid a dsRNA response. Much of the current effort in the lab is directed toward a molecular understanding of the RNAi machinery and its roles in the cell. RNAi is not the only cellular defense against unwanted nucleic acid, and substantial current effort in the lab is also directed at identification of other triggers and mechanisms used in recognition and response to foreign information.

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