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8. Hermann Staudinger Lecture mit Nobelpreisträger Robert Huber

Robert Huber

"Intracellular Proteolysis: Mechanisms, Structures, and Application"

Nobel Laureate Robert Huber, Max Planck Institute of Biochemistry, Martinsried

The Nobel Prize in Chemistry 1988 was awarded jointly to Johann Deisenhofer, Robert Huber and Hartmut Michel "for the determination of the three-dimensional structure of a photosynthetic reaction centre".

"Intracellular Proteolysis: Mechanisms, Structures, and Application"
Wann 16.12.2010
von 17:15 bis 18:15
Wo Chemistry Lecture Hall, Albertstr. 21, 79104 Freiburg
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Teilnehmer öffentlich / open to the public
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Intracellular Proteolysis: Mechanisms, Structures, and Application

Within cells or subcellular compartments misfolded and/or short-lived regulatory proteins are degraded by protease machines, cage-forming multi-subunit assemblages. Their proteolytic active sites are sequestered within the particles and located on the inner walls. Access of protein substrates is regulated by protein subcomplexes or protein domains which may assist in substrate unfolding dependent of ATP. Five protease machines will be described displaying different subunit structures, oligomeric states, enzymatic mechanisms, and regulatory properties.

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Report on the 8th Hermann Staudinger Lecture with Robert Huber:

Last Wednesday’s guest in the Hermann Staudinger Lecture series was Nobel Laureate Robert Huber from the Max Planck Institute of Biochemistry in Martinsried. Robert Huber received the Nobel Prize for Chemistry in 1988 together with Johann Deisenhofer and Hartmut Michel. They were recognized for their work in first crystallizing an intramembrane protein important in photosynthesis in purple bacteria, and subsequently applying X-ray crystallography to elucidate the protein's structure. His work contributed enormously to the development of methods in protein crystallography and their refinement, as well as to the development of new instruments for crystallography. Although retired he is still an active member in research which showed in his inspiring talk on proteases. His talk was a tour de force from first time discoveries to current research on protease function convincing the auditorium in the Hermann Staudinger Lecture on how important the “daily role” of proteases in the cellular environment is. He presented an important medical application of the first therapeutic proteasome inhibitor Bortezomib, marketed as Velcade, for the treatment of multiple myeloma. Impressive 3D-images of crystal structures depicted the role and function of different proteasome inhibitors and the link from structure via function to a deeper understanding of cellular processes in general.
(Melanie Börries)

Poster:

staudinger 8 huber poster