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29. Hermann Staudinger Lecture mit Nobelpreisträgerin Ada Yonath


Prof. Ada E. Yonath; at Dept. of Computational Biology&Bioinformatics, University of Kerala during her visit to Kerala in 2013 Feb. Photography by Hareesh N. Nampoothiri (Haree0, NEWNMEDIA™


Ada Yonath

Structural Biology Department
Weizmann Institute of Science, Rehovot, Israel     

                                                                                                                 

by Hareesh N. Nampoothiri (Haree), NEWNMEDIA™. [CC BY-SA 3.0]

Next generation eco-friendly antibiotics, and thoughts about origin of life
Wann 04.05.2020
von 16:15 bis 17:30
Wo FRIAS, Albertstr. 19, Anatomy Lecture Hall
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Teilnehmer öffentlich / open to public
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Next generation eco-friendly antibiotics, and thoughts about origin of life

 

Ribosomes are the universal cellular machinery that translate the genetic code to proteins. Owing to their high significance, in bacteria they are targeted by many antibiotics.  Structures of complexes of eubacterial ribosomes with the commonly used antibiotics that paralyze them, illuminated common pathways in their inhibitory-actions, synergism, differentiation and resistance. Comparisons of structures of ribosomes from multi-resistant pathogens to those of harmless bacteria illuminated unique features that may provide sites for the design of novel, next generation, species-specific antibiotics, thus microbiome preserving and degradable, thus eco-friendly.

Inspection of all known ribosome structures led to identification of a semi-symmetric highly conserved region, in which the peptide bonds are being formed. Since evolution independent, this region is suggested to be the proto-ribosome, namely the prebiotic molecular machine forming peptide bond, hence being the origin of life.