Prof. Dr. Stefan Eimer
Stefan Eimer is a Professor for Structural cell Biology in the BIOSS excellence cluster. His research focuses on a molecular and structural understanding of molecular membrane trafficking and its control by small Rab GTPases. His group tries to understand how membrane transport and quality control are altered in ageing and disease.
Stefan Eimer studied Biochemistry at the university in Bayreuth and graduated in 2002 at the Gene Center of the Ludwig-Maximilians University in Munich working on Alzheimer's disease model in the nematode Caenorhabditis elegans. After a postdoctoral stay at the Ecole Normale Superieure in Paris, he established his own group as an independent group leader at the European Neuroscience Institute in Göttingen in 2005, analysing the molecular mechanisms leading to Parkinson's disease. In 2012 he was appointed W2 Professor for Structural Cell Biology at the Albrecht-Ludwigs University in Freiburg.
- Ailion M., Hannemann M., Dalton S., Pappas A.,Watanabe S., Hegermann J., Liu Q., Han H.-F., Gu M., Goulding M.Q., Sasidharan N., Schuske K., Hullett P., Eimer S., and Jorgensen E.M. (2014) Two Novel Rab2 Interactors Regulate Dense-core Vesicle Maturation. Neuron; 82(1):167-80.
- Kittelmann M., Liewald J.F., Hegermann J., Schultheis C., Brauner M., Steuer Costa W., Wabnig S., Eimer S.*, Gottschalk A.* (2013) In vivo synaptic recovery following optogenetic hyperstimulation. (*corresponding authors) PNAS; 110(32): E3007-3016.
- Sasidharan N., Sumakovic M., Hannemann M., Hegermann J., Liewald H., Olendrowitz C., Grant B.D., Rizzoli S.O., Gottschalk A. and Eimer S. (2012) Selective regulation of dense core vesicle release by a novel Rab cascade in Caenorhabditis elegans. PNAS; 109(46):18944-9.
- Hannemann M., Sasidharan N., HegermannJ., Koenig S. and Eimer S. (2012) TBC-8, a novel RAB-2 GAP involved in dense core vesicle maturation in C. elegans. PLoS Genetics; 8(5):e1002722.
- Witte K., Schuh A.L., Sarkeshik A., Hegermann J., Mayers J.R., Schwarze K., Yates III J.R., Eimer S., and Audhya A. (2011) Mechanisms by which TFG functions in protein secretion and oncogenesis. Nat. Cell Biol., 13(5):550-8.
Regulation of mitochondrial integrity by Rab GTPase mediated control of mitophagy
Small GTPases of the Rab family are master-regulators of intracellular trafficking and sorting events between different membrane domains. Rab GTPases function thereby as molecular switches which recruit in their ON, GTP-bound, state a set of effector molecules that execute downstream events. In addition to their control of multiple steps during vesicular membrane transport, Rab GTPases also provide identity to intracellular membrane structures and organelles, facilitating directed transport. However, despite our basic knowledge about general Rab GTPase function, the mechanisms of Rab GTPase mediated crosstalk between different organelles to maintain cellular homeostasis is not well understood. Interestingly, through genetic screens in the nematode Caenorhabditis elegans we have identified the Rab GTPase GLO-1, which is involved in trafficking to the lysosome related organelle, to be required for mitochondrial integrity and function. Thus glo-1 mutants might be a good model system to understand lysosomal storage diseases.