Dr. Verónica I. Dumit
November 2013 - Juli 2014
Verónica Dumit obtained her First Degree in Biotechnology in 2005 at the University of Rosario, Argentina, where she also completed her Doctoral Thesis in 2011, at the Department of Molecular Biology. Part of her graduate studies was done at the University of Bayreuth, Germany, in the Department of Computational Biochemistry, in the frame of a DAAD fellowship. In June 2011, she joined the group of Dr. Jörn Dengjel as postdoctoral fellow in the School for Life Sciences-LifeNet at FRIAS. In 2013 she was awarded a Junior Fellowship by FRIAS to develop her own independent research project.
- Dumit, VI; Küttner, V; Käppler, J; Piera-Velazquez, S; Jimenez, SA; Bruckner-Tuderman, L; Uitto, J and Dengjel, J.(2012) Proteomics Profiling Suggests Molecular Similarities between Aging and Systemic Sclerosis Dermal Fibroblasts: Altered MCM Complexes and Autophagic Flux. Submitted.
- Dumit, VI and Dengjel J. Autophagosomal protein dynamics and influenza virus infection. (2012) Front. Immun., 3, 43.
- Ullmann, GM; Dumit, VI and Bombarda, E. Methods Based on Continuum Electrostatics and Their Application to Flavoproteins. (2012) In Handbook of Flavoproteins (Susan Miller, Bruce Palfey and Russ Hille, eds) De Gruyter, 335-360.
- Dumit, VI; Cortez, N and Ullmann, GM. (2011) Distinguishing two groups of flavin reductases by analyzing the protonation state of an active site carboxylic acid. Proteins, 79: 2076–2085.
- Dumit, VI; Essigke, T; Cortez, N and Ullmann, GM. (2010) Mechanistic insights into ferredoxin catalysis involving the conserved glutamate in the active site. J. Mol. Biol., 397, 814-25.
Involvement of MCM helicase proteins in skin aging and fibrotic disorders
Verónica’s project deals with two biological processes, skin aging and fibrosis, and it aims at understanding common metabolic pathways involved in both phenomena. Aging has rapidly become a topic of broad interest, since the average life span has increased by 30 years in the last century. Since aging is the common feature shared by many diseases, it has been proposed to be an adequate target to treat all age-related diseases simultaneously. Understanding how aging increases risk of diabetes, cardiovascular diseases, cancer, dementia and Alzheimer's disease, among other age-related pathologies, is key to improve health during aging. Particularly, and based on previous results, this project studies the involvement of mini-chromosome maintenance (MCM) helicase proteins in skin aging and fibrotic disorders.