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Lena Köhler

Medizinische und Pharmazeutische Chemie - AK Müller
Postdoc with External Senior Fellow Katarina Edwards

    CV

    Lena Koehler received her diploma in food chemistry in 2006 from the Technische Universität Dresden. Afterwards, she carried out her PhD studies under the supervision of Prof. J. Steinbach at the research centre Dresden-Rossendorf. In 2010 she got her PhD from the Technische Universität Dresden with a dissertation on “Radiotracers for molecular imaging of cell cycle components: radiolabelling of Cdk4/6-inhibitors with short-lived radionuclides iodine-124 and fluorine-18”. Since November 2010 she is working as a Postdoc in the group of the External Senior Fellow Prof Katarina Edwards at the Soft Matter School of FRIAS on the topic "Stabilizing lipid disks via in situ cross-linking".

     

    FRIAS Project

    Synthesis of modified PEG-Phospholipids for preparation of stabilized lipid disks

     

    Selected Publications

    1. L. Koehler, K. Gagnon, S. McQuarrie, F. Wuest: Iodine-124: A promising positron emitter for organic PET chemistry. Molecules 2010, 15, 2686-2718
    2. L. Koehler, F. Graf, R. Bergmann, J. Steinbach, J. Pietzsch, F. Wuest: Radiosynthesis and radiopharmaco-logical evaluation of cyclin-dependent kinase 4 (Cdk4) inhibitors. Eur J Nuc Med 2010, 45, 727-737
    3. F. Graf, L. Koehler, T. Kniess, F. Wuest, B. Mosch, J. Pietzsch: Cell cycle regulating kinase Cdk4 as a potential target for tumor cell treatment and tumor imaging. J Oncol 2009, doi:10.1155/2009/106378
    4. F. Wuest, L. Koehler, M. Berndt, J. Pietzsch: Systematic comparison of two novel, thiol-reactive prosthetic groups for 18F labeling of peptides and proteins with the acylation agent succinimidyl-4-[18F]fluorobenzoate ([18F]SFB). Amino Acids 2009, 36, 283-295