Michael Müller: "Biomimetic Chemoenzymatic Synthesis of Pharmaceuticals"
von 11:15 bis 12:00
|Wo||FRIAS Seminarraum, Albertstraße 19|
|Kontakttelefon||+49 761 203 97418|
Prof. Michael Müller
Institute of Pharmaceutical Sciences, Freiburg University
Biomimetic chemoenzymatic synthesis of pharmaceuticals
Natural products are privileged structures in terms of structural diversity and bioactivity. Although the biosynthetic routes towards many bioactive ‘secondary metabolites’ have been elucidated, the reason(s) for their production in natural environment is often elusive. We are interested in deciphering biosynthetic strategies in order to use these strategies for biomimetic access towards putative bioactive compounds. This approach is exemplified by the polyketide and shikimate biosynthetic routes resulting in diversity-oriented production of novel chrial building blocks.