PhD Student with Junior Fellow Jörn Dengjel
Britta Diedrich started her career as a Government certified biological-technical assistant in 2000 and worked in this profession at the Max-Planck-Institute for Infection Biology, Berlin, at the Department of Anesthesiology and Intensive Care Medicine, University Medical Center of Bonn and at the Institute of Medical Microbiology, Immunology and Hygiene, University Hospital of Cologne. From 2004 to 2009 she studied Biology at the University of Düsseldorf, where she obtained her diploma in 2010 on the subject of „Pathological mechanisms during natural immunity by sepsis and its regulation through antibiotics“. From 2009 onwards Britta Diedrich worked as a research assistant at the University Medical Centers of Bonn and Düsseldorf before she moved to the Laboratory for Bioinformatics and Molecular Genetics at the Albert Ludwigs-University in Freiburg. In 2012 she joined Jörn Dengjels group as a PhD student.
Malignant cell transformation during tumor progression is a continuous process, leading to modifications in gene expression, protein abundance/turnover, metabolism, and, particular, protein localization. Actually little is presently known on how the subcellular localization and composition of cytosolic protein complexes relate to tumor progression. I use protein profiling (pp) SILAC to study spatiotemporal dynamics of non-membranebound, macromolecular protein complexes during oncogene-induced cell transformation in Caco 2 cells, an epithelial colorectal adenocarcinoma cell line.