Hagai Abeliovich: "Proteomic approaches to the study of stationary phase mitophagy"
von 10:15 bis 11:00
|Wo||ZBSA (Seminarraum im UG), Habsburgerstr. 49, 79104 Freiburg|
|Kontakttelefon||+49 761 203 97208|
Open to University employees
Hebrew University of Jerusalem, Rehovot, Israel
Proteomic approaches to the study of stationary phase mitophagy
The clearance of malfunctioning mitochondria is an important housekeeping function in respiring eukaryotic cells, and plays a role in physiological homeostasis as well as in the progression of late-onset diseases such as Parkinson’s disease. This clearance is thought to occur by a specific form of autophagic degradation called mitophagy. We discovered conditions under which mitophagy is massively induced in yeast, and identified a number of factors that contribute to this process. Key open questions, regarding mitophagy, are whether there exist selectivity mechanisms that segregate functional mitochondrial sub-compartments from dysfunctional ones, and the nature of the molecular signals that identify the ‘defective’ mitochondria. By using a proteomic approach coupled with yeast genetics, we have identified putative molecular lesions that may be linked to such a segregation process, as well as evidence for apparent selectivity mechanisms. These data allow us to generate testable models for mitochondrial protein segregation during mitophagy.